A neurotoxin called acrolein found in tobacco smoke that is thought to increase pain in people with spinal cord injury has now been shown to accumulate in mice exposed to the equivalent of 12 cigarettes daily over a short time period. One implication is that if acrolein is exacerbating pain its concentration in the body could be reduced using the drug hydralazine, which has been approved by the U.S. Food and Drug Administration for hypertension. The drug has been shown to be effective in reducing acrolein levels in research animals, and Shi is working to develop a low–dose version for that purpose in humans.
Taken from MDLinx summary of an article found at Purdue University Research news
The U.S. Food and Drug Administration approved Hysingla ER (hydrocodone bitartrate), an extended–release (ER) opioid analgesic to treat pain severe enough to require daily, around–the–clock, long–term opioid treatment and for which alternative treatment options are inadequate.
Hysingla ER has approved labeling describing the product’s abuse–deterrent properties consistent with the FDA’s 2013 draft guidance for industry, Abuse–Deterrent Opioids – Evaluation and Labeling. Hysingla ER has properties that are expected to reduce, but not totally prevent, abuse of the drug when chewed and then taken orally, or crushed and snorted or injected.
The tablet is difficult to crush, break or dissolve. It also forms a viscous hydrogel (thick gel) and cannot be easily prepared for injection. The FDA has determined that the physical and chemical properties of Hysingla ER are expected to make abuse by these routes difficult. However, abuse of Hysingla ER by these routes is still possible. It is important to note that taking too much Hysingla ER, whether by intentional abuse or by accident, can cause an overdose that may result in death.
Taken from DailyRx and FDA Press Announcements provided by MDLinx
If you suffer from chronic knee pain, you'll want to hear more about a new study involving acupuncture. I'm Rachelle Grossman with your latest health news.
Researchers set out to test whether laser or needle acupuncture reduced a patient's knee pain or improved knee function. Many doctors and patients prefer to use treatments that do not involve medication or surgery for knee pain. Acupuncture is a practice in which a patient's skin is pricked with needles to reduce pain and treat a host of other conditions. The study found that, although acupuncture produced modest improvements in the short term, the reduced pain and increased knee function didn't last for more than a year in patients 50 or older.
Doctors recommend you stay active to maintain healthy joints.
Taken from DailyRX.
According to a new position statement from the American Academy of Neurology (AAN), the risk of death, overdose, addiction or serious side effects with prescription opioids outweigh the benefits in chronic, non–cancer conditions such as headache, fibromyalgia and chronic low back pain. The position paper is published in the September 30, 2014, print issue of Neurology.
“More than 100,000 people have died from prescription opioid use since policies changed in the late 1990s to allow much more liberal long–term use,” said Gary M. Franklin, MD, MPH, research professor in the Department of Environmental & Occupational Health Sciences in the University of Washington School of Public Health in Seattle and a Fellow with the AAN. “There have been more deaths from prescription opioids in the most vulnerable young to middle–aged groups than from firearms and car accidents. Doctors, states, institutions and patients need to work together to stop this epidemic.”
Studies have shown that 50 percent of patients taking opioids for at least three months are still on opioids five years later. A review of the available studies showed that while opioids may provide significant short–term pain relief, there is no substantial evidence for maintaining pain relief or improved function over long periods of time without serious risk of overdose, dependence or addiction. The AAN recommends that doctors consult with a pain management specialist if dosage exceeds 80 to 120 (morphine–equivalent dose) milligrams per day, especially if pain and function have not substantially improved in their patients.
Taken from American Academy of Neurology News
A new antibody appears to block two unpleasant nerve signals. Duke University researchers have found an antibody that simultaneously blocks the sensations of pain and itching in studies with mice. The new antibody works by targeting the voltage–sensitive sodium channels in the cell membrane of neurons. The results appear online on May 22 in Cell.
Voltage–sensitive sodium channels control the flow of sodium ions through the neuron's membrane. These channels open and close by responding to the electric current or action potential of the cells. One particular type of sodium channel, called the Nav1.7 subtype, is responsible for sensing pain. Mutations in the human gene encoding the Nav1.7 sodium channel can lead to either the inability to sense pain or pain hypersensitivity.
Interestingly, these mutations do not affect other sensations such as touch or temperature. Hence, the Nav1.7 sodium channel might be a very specific target for treating pain disorders without perturbing the patients' ability to feel other sensations.
Taken from Duke University Health & Medicine News
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